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Autoimmun Rev (2014) 13(4-5):3917
This enabled commercial use even without full drug approval
Figure 2 3.1 Activation of inflammatory signaling pathways Research indicates that increased intestinal permeability allows endotoxins such as LPS to enter the systemic circulation, where they trigger systemic inflammatory responses by activating the Toll-like receptor 4/nuclear factor kappa-light-chain-enhancer of activated B cells (TLR4/NF-B) inflammatory pathway
Platforms obtained in this manner retain the specificity of TME-oriented design yet remain relatively compatible with existing pathways for manufacturing, quality control and safety assessment in drug development [61,62,63]
TABLE 9 Rut can protect blood brain barrier
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